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While minimal-rely MBL hardly ever progresses to CLL, substantial-rely MBL progresses to CLL demanding therapy at a amount of 1% to 2% annually. High-depend MBL is distinguished from Rai 0 CLL according to whether the B-cell rely is above or down below 5 × 109/L. Although persons with both higher-rely MBL and CLL Rai stage 0 are at increased risk